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KMID : 0939920190510020664
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대한암학회지
2019 Volume.51 No. 2 p.664 ~ p.671
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Albumin-to-Fibrinogen Ratio as an Independent Prognostic Parameter in Untreated Chronic Lymphocytic Leukemia: A Retrospective Study of 191 Cases
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Zou Yi-Xin
Qiao Jia
Zhu Hua-Yuan
Lu Rui-Nan
Xia Yi
Cao Lei
Wu Wei
Jin Hui
Liu Wen-Jie
Liang Jin-Hua
Wu Jia-Zhu
Wang Li
Fan Lei
Xu Wei
Li Jian-Yong
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Abstract
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Purpose: Chronic lymphocytic leukemia (CLL) is one of the most frequent type of B-cell chronic lymphoproliferative disorders and chronic inflammation takes part in the development of CLL. However, there has been no valid immune biomarker to predict the prognosis of untreated CLL patients.
Materials and Methods: In this retrospective study, we analyzed the clinical correlations and prognostic value of albumin-to-fibrinogen ratio (AFR) detected at diagnosis in 191 CLL patients.
Results: The cut-off value of AFR was 9.7 calculated by X-tile. Patients who were more than 65 years old were often accompanied by low level of AFR (p < 0.001). Survival analysis showed that patients with low level of AFR had shorter overall survival (OS) than patients with high level of AFR (p < 0.001). Multivariate analysis illustrated that AFR had a negative impact on OS (p=0.003) and was independent of parameters involved in CLL international prognostic index and other prognostic markers such as CD38 and ZAP-70.
Conclusion: These data provide a comprehensive view of AFR and shows that AFR at diagnosis is an adverse prognostic factor in untreated CLL patients.
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KEYWORD
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Serum albumin, Fibrinogen, B-cell chronic lymphocytic leukemia, Prognosis
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